NUCLEODUR is a fully synthetically type B silica (silica of 3rd generation) offering highly advanced physical properties: Totally spherical particle shape. Outstanding surface microstructure. High pressure stability. Low metal content. NUCLEODUR as a state-of-the-art silica is the ideal base material for modern HPLC phases. It is the result of MACHEREY-NAGEL's pioneering research in chromatography for almost 50 years.