With the introduction of the Combitip/Multipette system, Eppendorf revolutionized the industry and laboratory operations in 1978, and has been the market leader in product innovation for over 38 years. The Eppendorf Combitips advanced have been completely revised and optimised all around to meet the increased demands of modern laboratory life even better. The Combitips advanced also work according to the direct displacement principle. This means that regardless of the density and flow properties of the liquid (e.g. higher vapour pressure or increased viscosity) always dispenses the right desired volume. Working with radioactive or toxic substances is also safer thanks to the hermetically sealed piston, as aerosol contamination is prevented.