Nexium 24HR is the all-day, all-night protection you can trust to deliver relief. Choose the brand that millions of people have taken to effectively protect themselves from frequent heartburn. Instructions Directions adults 18 years of age and older this product is to be used once a day (every 24 hours), every day for 14 days may take 1 to 4 days for full effect14-Day Course of Treatment swallow 1 capsule with a glass of water before eating in the morning take every day for 14 days do not take more than 1 capsule a day swallow whole. Do not crush or chew capsules. do not use for more than 14 days unless directed by your doctor