Built-in muli-parameters internal/external process indicators that change color when all three criteria for sterilization have been met – time, temperature and pressure (steam). manufactured from medical grade paper with extra-wide Chevron to protect against instrument breaching, thumb-notched for easy opening, 6 corner tack seals to prevent curling and other potential contaminants from entering pouch upon opening and a perforated fold to help ensure the adhesive strip forms an Airtight seal.