Xyzal now offers exceptional value over the counter with the same original prescription strength. Xyzal is proven to be as effective at hour 24 as it is at hour one, so you can count on long-lasting relief from symptoms such as sneezing, runny nose, itchy/watery eyes, and itchy nose or throat. Xyzal contains the active ingredient levocetirizine dihydrochloride and is an antihistamine pill.