The Large Miracle Nipple is truly the “Next best thing to mom”! Designed for larger suckling baby animals such as medium to large breed puppies. The Miracle Nipple has a pre-made hole. The large miracle nipple will fit a luer lock tip syringe and a standard size baby bottle. Included in the package of two nipples are also a 1 -10 ml and 1 - 20ml luer lock tip Miracle Brand Oring syringes. Due to chances of aspiration when using a bottle, we recommend starting with the syringes included in the package, always starting with a smaller syringe first. The Miracle Nipple is designed and manufactured in the USA. Pkg includes 1 -10 ml and 1 - 20ml luer lock tip Miracle Brand Oring syringes.