FRIO Insulin Cooling Cases provide a highly effective, yet low-cost solution to the problem of keeping insulin at a safe temperature without the need for ice packs or refrigeration. The FRIO Cooling Case is a reusable evaporative cooler whose cooling properties do not come from an icepack - or anything that needs refrigeration. How Long Do FRIOs Stay Cold? FRIO wallets keep insulin safe for up to 45 hours (more than five times longer than an ice pack) — even in constant environmental temperatures of 100 degrees Fahrenheit! How do you use a FRIO? To activate the FRIO wallet, immerse it in cold water for 5-15 minutes. Just towel dry the outside and it's ready to go! After towel-drying, the FRIO wallet is dry to the touch. The Cambrelle outer pouch wallet increases the wallet's efficiency and allows it to be carried safely in your pocket or a bag as required to use it again, put the FRIO back in water — it can be reactivated over and over again. What a great option for your Emergency Preparedness bag! You'll keep your medication cool during power outage events such as fire, hurricane, blizzard, and tornados. ***Please check your medication's storage requirement to see if it is suitable for the FRIO cooling cases. If you are not sure, consult your physician.