From the number one pediatrician-recommended lice removal brand.* Nix Ultra Lice Treatment All-in-One Shampoo is specifically designed to kill superlice. Superlice are the dominant species of head lice and are resistant to traditional pesticide lice treatments. Nix Ultra treatments are pesticide-free and non-toxic. They work by killing lice and superlice through suffocation rather than using harsh chemicals. First, apply Nix Ultra All-in-One Shampoo to hair. Then, remove lice and eggs (nits) from head hair with the Nix Ultra Lice Removal Comb. Nix Ultra All-in-One Shampoo is for use on head hair and safe for use on children 1 year and older. No additional shampoo is needed-, Nix Ultra lice shampoo cleans hair while killing superlice and eggs (nits). Nix lice treatment is trusted by parents and feared by lice. Nix offers a variety of lice combs, shampoos, treatment kits, hair prevention spray and lice spray for furniture and bedding to nix out lice in your home. *Based on Pediatrician Survey December 6, 2022.